1. Half Man/Half Incredible

To save Loren's life after a catastrophic forklift accident, doctors had to cut him in half. Sofia was an active 29-year-old when her heart went into end-stage failure. Now she must be plugged-in to stay alive.

2. Aged and Born Fused

Tiffany has progeria, a condition that causes her to age rapidly -- yet she's already outlived her life expectancy. Single dad Ryan was born with Arthrogryposis, leaving his arms and legs fused.

4. Fading Confetti

Kirtus developed vitiligo, alopecia, and bone loss from an allergic reaction; a surgery may transform his life. Portia has an extremely rare skin condition affecting possibly under 25 people globally.

5. Speaking of Skin

Caroline can only safely eat two foods without risking anaphylaxis. Ariana's butterfly skin blisters and tears from nearly any contact. Aleazia's cystic hygroma swelled his jaw and tongue, leaving his mouth permanently open.

6. ⁨Walk the Walk, Talk the Talk⁩

Zahra is confined at home by a rare condition, but new prosthetics could grant her freedom. Mahogany's leg weighs almost 100 pounds from lymphedema. Joseph was born without a jaw yet refuses to let it hold him back.

7. Small Insights

Twenty-seven-year-old Taffy presents physically as a 4-year-old; Adrienne's rare disorder has left both her eyes completely covered by skin; Baby Brody undergoes a procedure to fix a severe cleft palate.

8. No Two the Same

Piyah must walk on her hands because she was born with a body that ends at her waist. Joe is the first survivor of a successful hands and face transplant. Tumors have left Reggie's face unrecognizable, and threaten his independence.