1. Biggest Hands

Mark's hands are 20 times bigger than a normal adult male's. After learning that his condition may require amputation, Mark stopped seeing doctors. Now troubling changes to his hands means he must go back. If not for himself, then for his young daughter.

2. Ugliest Man

Winner of the Uganda's Ugliest Man contest, Godfrey has a disorder that has left him disfigured.

3. Upside Down With a Twist

In Brazil, Claudio lives with a condition that bent his head backward.