1. San Francisco

Season 2 begins with comedians Jay Larson and Sean Patton getting punch drunk with Nat Faxon in San Francisco.

2. Washington D.C.

Jay and Sean visit Washington, D.C., and drink from the country's largest whiskey collection, check out a new brewery in the old Navy yard and make booze the colonial way in the home of America's first president.

3. Louisville

Jay and Sean visit Louisville and learn there is a lot more than whiskey in bourbon country. They sip a cocktail with a haunted history, go nose-to-tail with char-grilled squirrel, and learn a palate-busting beer lesson from the Brew Dogs.

4. Minneapolis

Jay and Sean take in the booze-cruising, polka-filled world of Minneapolis, where they snack on pig's head, enter meat raffles and compete in a home brew-themed curling tournament.

5. Speakeasies

Jay and Sean walk through armoires, sneak in back doors and slide away bookcases to reveal the Cuban flair, coin tricks and innovative cocktails of the modern and well-hidden speakeasy. Aisha Tyler appears.

6. Southern California Coast

Jay and Sean visit the Southern California coast, where they find an old stagecoach stop in the mountains of Santa Barbara, a pop-up culinary cocktail bar in a Venice garden and a beach-front dive with ice cold beer. Comedian Bill Burr appears.

7. Booze and Food

Jay and Sean search for the best bar food in America. In San Francisco, they toss dough with a champion pizza maker. In Chicago, they learn the true meaning of going "whole hog"; and in Los Angeles they nearly drown in nacho cheese with comedian Al Madrigal.

8. Chicago

Jay and Sean visit Chicago and learn about booze's mobster roots. They get the Picasso treatment at a neighborhood landmark, take in the comedy scene with Pete Holmes, and get a taste of local music with blues legend Buddy Guy.

10. Bar Games

Season 2 ends with Jay and Sean playing bingo, beer pong and virtual golf at the best game bars in the country. They also get heckled at a renaissance fair, test their smarts with comedian Kyle Kinane and strike out with swimsuit model Nina Agdal.